The application of QCT in the prognostic assessment of mCRC undergoing first-line treatment based on bevacizumab.

ABSTRACT:

Background

Bevacizumab induces muscle atrophy by changing the gene expression level of muscle tissue. Quantitative computed tomography (QCT) enables precise measurement of various body compositions, including muscle area.

Materials & methods

A total of 102 patients with metastatic colorectal cancer (mCRC) undergoing first-line chemotherapy based on bevacizumab were enrolled at thirst Affiliated Hospital of the University of Science and Technology of China. Their body compositions were measured respectively 1 month before and 1 month after the treatment.

Results

Treatment-related decline in skeletal muscle index and visceral fat infiltration significantly affect patient prognosis.

Conclusion

A predictive model constructed by integrating changes in body compositi

SUBMITTER: Liu X 

PROVIDER: S-EPMC11776858 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature