GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors.

ABSTRACT:

Background

Based on sequence similarity, the superfamily of G protein-coupled receptors (GPRs) can be subdivided into several subfamilies, the members of which often share similar ligands. The sequence data provided by the human genome project allows us to identify new GPRs by in silico homology screening, and to predict their ligands.

Results

By searching the human genomic database with known nucleotide receptors we discovered the gene for GPR99, a new orphan GPR. The mRNA of GPR99 was found in kidney and placenta. Phylogenetic analysis groups GPR99 into the P2Y subfamily of GPRs. Based on the phylogenetic tree we propose a new classification of P2Y nucleotide receptors into two subgroups predicting a nucleotide ligand for GPR99. By assaying known nucleotide ligands on hete

SUBMITTER: Wittenberger T 

PROVIDER: S-EPMC117779 | biostudies-literature | 2002 Jul

REPOSITORIES: biostudies-literature