Innovative antifungal strategies: enhanced biofilm inhibition of <i>Candida albicans</i> by a modified tea tree oil formulation.

ABSTRACT:

Introduction

Candida albicans is a significant human pathogen with the ability to form biofilms, a critical factor in its resistance to antifungal treatments. This study aims to evaluate the antifungal activity and biofilm inhibition potential of Tea Tree Oil (TTO) derived from Melaleuca alternifolia cultivated in Vietnam.

Methods

The antifungal activity of TTO was assessed by determining the Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC), Minimum Biofilm Inhibitory Concentration (MBIC), and Minimum Biofilm Eradication Concentration (MBEC) using broth dilution methods. The experiments were conducted on C. albicans in both planktonic and biofilm states across concentrations ranging from 0.1 μL/mL to 10 μL/mL.

Results

SUBMITTER: Tuan DA 

PROVIDER: S-EPMC11778174 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature