The IclR-family transcriptional regulator XyrR controls flotation, motility, antibiotic production and virulence in <i>Serratia</i> sp. ATCC 39006.

ABSTRACT: The opportunistic pathogen Serratia sp. ATCC 39006 (S39006) is a rod-shaped, motile, Gram-negative bacterium that produces a 𝛽-lactam antibiotic (a carbapenem) and a bioactive red-pigmented tripyrrole antibiotic, prodigiosin. It is also the only known enterobacterium that naturally produces intracellular gas vesicles (GVs), enabling cells to float in static water columns. Regulation of GVs and secondary metabolites in S39006 can be coordinated but such pleiotropy is still poorly understood. To uncover novel inputs to this complex regulatory network, we used transposon mutagenesis to identify a mutant with an insertion in an IclR-type transcriptional regulator gene. The iclR mutant showed diminished production of carbapenem, prodigiosin, GVs and cellulase. Furthermore, the mu

SUBMITTER: Sandoval CMC 

PROVIDER: S-EPMC11778176 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature