Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.

ABSTRACT:

Background

Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood. One way to assess this heterogeneity is to look for patterns in the subphenotype data. Because of the variability in how phenotypic data was collected by the various BD studies over the years, homogenizing this subphenotypic data is a challenging task, and so is replication. An alternative methodology, taken here, is to set aside the intricacies of subphenotype and allow the genetic data itself to determine which subjects define a homogeneous genetic subgroup (termed 'bicluster' below).

Results

In this paper, we leverage recent advances in heterogeneity analysis to look for genetica

SUBMITTER: McGrouther CC 

PROVIDER: S-EPMC11778664 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature