Efficacy and safety of <i>Oxalobacter formigenes</i> in patients with primary hyperoxaluria: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background and objective

Primary hyperoxaluria (PH), a rare autosomal recessive disorder, results in defective metabolism of oxalate, leading to increased oxalate levels. Oxalobacter formigenes (O. formigenes) is a nonpathological anaerobic bacterium that uses oxalate for its survival and thus decreases the plasma oxalate levels. We aimed to use randomized controlled trials (RCTs) to evaluate the efficacy of O. formigenes in treating PH.

Methods

A literature review was conducted for synthesizing the evidence from RCTs on Scopus, Web of Science, Embase, PubMed, and CENTRAL until January 2023. The outcomes were pooled using mean difference (MD) for continuous data and odds ratios (OR) for dichotomous data along with confidence interval (CI). The systematic review

SUBMITTER: Khan U 

PROVIDER: S-EPMC11778695 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature