Scrub typhus association with autoimmune biomarkers and clinical implications.

ABSTRACT:

Background

Scrub typhus, a disease caused by Orientia tsutsugamushi, triggers systemic vasculitis and is prevalent in Eastern and Southern Asia. This study aimed to uncover the relationship between scrub typhus and autoimmune responses, focusing on antinuclear antibodies (ANAs) and the implications of elevated ANA titers during infection.

Method

Data from a total of 139 patients diagnosed with scrub typhus and 30 healthy controls were retrospectively analyzed through serum samples to assess the levels of ANAs and related autoantibodies. The study further examined the temporal variation of these antibody titers in relation to post-symptom progression and evaluated their association with clinical and laboratory parameters.

Results

The study results detail significant di

SUBMITTER: You H 

PROVIDER: S-EPMC11778775 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature