Neural activity during working memory predicts clinical response to computerized executive function training prior to cognitive processing therapy.

ABSTRACT:

Background

Executive dysfunction, including working memory deficits, is prominent in posttraumatic stress disorder (PTSD) and can impede treatment effectiveness. Intervention approaches that target executive dysfunction alongside standard PTSD treatments could boost clinical response. The current study reports secondary analyses from a randomized controlled trial testing combined PTSD treatment with a computerized training program to improve executive dysfunction. We assessed if pre-treatment neurocognitive substrates of executive functioning predicted clinical response to this novel intervention.

Methods

Treatment-seeking veterans with PTSD (N = 60) completed a working memory task during functional magnetic resonance imaging prior to being randomized to six weeks of

SUBMITTER: Davey D 

PROVIDER: S-EPMC11779553 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature