Prefrontally mediated inhibition of memory systems in dissociative amnesia.

ABSTRACT:

Background

The mechanisms underlying generalized forms of dissociative ('psychogenic') amnesia are poorly understood. One theory suggests that memory retrieval is inhibited via prefrontal control. Findings from cognitive neuroscience offer a candidate mechanism for this proposed retrieval inhibition. By applying predictions based on these experimental findings, we examined the putative role of retrieval suppression in dissociative amnesia.

Methods

We analyzed fMRI data from two previously reported cases of dissociative amnesia. Patients had been shown reminders from forgotten and remembered time periods (colleagues and school friends). We examined the neuroanatomical overlap between regions engaged in the unrecognized compared to the recognized condition, and the regions eng

SUBMITTER: Marsh LC 

PROVIDER: S-EPMC11779556 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature