Incorporation of the central vein sign into the McDonald criteria.

ABSTRACT:

Background

Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.

Objective

Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.

Methods

Data were obtained from the CAVS-MS Pilot, a cross-sectional, international multi-center study conducted by the North American Imaging in MS Cooperative (NAIMS) that recruited adults referred for suspicion/diagnosis of demyelinating disease. Diagnostic performance of methods incorporating CVS into McD 2017 radiological DIS were eva

SUBMITTER: Amin M 

PROVIDER: S-EPMC11779579 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature