Implication of fibroblast growth factor 7 in ovarian cancer metastases and patient survival.

ABSTRACT:

Background/objectives

Patients with ovarian cancer commonly experience metastases and recurrences, which contribute to high mortality. Our objective was to better understand ovarian cancer metastasis and identify candidate biomarkers and drug targets for predicting and preventing ovarian cancer recurrence.

Methods

Transcripts of 770 cancer-associated genes were compared in cells collected from ascitic fluid versus resected tumors of an ES-2 orthotopic ovarian cancer mouse model. Associated cell types and pathways were explored with bioinformatics. FGF7 protein was measured using capillary-based immunoassays or ELISA in mouse and clinical specimens. Significances of differential gene expression and patient prognosis were determined by volcano plot and log-rank test, respectiv

SUBMITTER: Mortan LF 

PROVIDER: S-EPMC11779605 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature