Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study.

ABSTRACT:

Background

Sepsis is a life-threatening condition caused by severe infection. The efficacy of intravenous immunoglobulin (IVIG) as adjunctive therapy on mortality remains controversial. Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).

Methods

This study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. We used a propensity score-matched analysis to compare outcomes between the IVIG and control groups. Primary outcomes were 28-day mortality, while secondary outcomes included in-ho

SUBMITTER: Takano H 

PROVIDER: S-EPMC11779611 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature