Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Mendelian randomization is believed to attenuate the biases inherent in observational studies, yet a meta-analysis of Mendelian randomization studies in osteoporosis has not been conducted thus far. This study aims to evaluate the connection between potential causal factors and the risk of osteoporosis by synthesizing evidence from Mendelian randomization studies.

Methods

The databases PubMed, Web of Science, and Embase were systematically searched for Mendelian randomization studies investigating factors influencing osteoporosis up to May 2024. Meta-analyses were conducted to assess the associations between various potential pathogenic factors and osteoporosis using Mendelian Randomization studies. The quality of the study was evaluated according to the Strengthe

SUBMITTER: Ji W 

PROVIDER: S-EPMC11779621 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature