Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production.

ABSTRACT: Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for therapeutic intervention in H. pylori disease progression. We have previously shown that spermine oxidase (SMOX), the enzyme that catabolizes the back-conversion of the polyamine spermine to spermidine, is upregulated during infection and is associated with increased cancer risk in humans. We sought to determine the direct role of SMOX in gastric carcinogenesis during H. pylori infection. In this study, we demonstrate that transgenic FVB/N insulin-gastrin (INS-GAS) mice that develop gastric carcinoma with H. pylori infection were protected from cancer development with Smox deletion. RNA sequencing revealed that genes associated with the immune system and cancer were downreg

SUBMITTER: McNamara KM 

PROVIDER: S-EPMC11779639 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature