Liver X receptor unlinks intestinal regeneration and tumorigenesis.

ABSTRACT: Uncontrolled regeneration leads to neoplastic transformation^1-3. The intestinal epithelium requires precise regulation during continuous homeostatic and damage-induced tissue renewal to prevent neoplastic transformation, suggesting that pathways unlinking tumour growth from regenerative processes must exist. Here, by mining RNA-sequencing datasets from two intestinal damage models^4,5 and using pharmacological, transcriptomics and genetic tools, we identified liver X receptor (LXR) pathway activation as a tissue adaptation to damage that reciprocally regulates intestinal regeneration and tumorigenesis. Using single-cell RNA sequencing, intestinal organoids, and gain- and loss-of-function experiments, we demonstrate that LXR activation in intestinal epithelial cells ind

SUBMITTER: Das S 

PROVIDER: S-EPMC11779645 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature