The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function.

ABSTRACT:

Introduction

Chimeric antigen receptor (CAR) expressing T-cells have shown great promise for the future of cancer immunotherapy with the recent clinical successes achieved in treating different hematologic cancers. Despite these early successes, several challenges remain in the field that require to be solved for the therapy to be more efficacious. One such challenge is the lack of long-term persistence of CD28 based CAR T-cells in patients. Although, CD28 based CAR T-cells elicit a robust acute anti-tumor response, they are more prone to early exhaustion, terminal differentiation and cell death due to their strong signaling patterns. Hence attenuation of signaling strength in CD28 based CARs is an accepted strategy to improve long-term CAR T-cell function and persistence in patien

SUBMITTER: Majumdar S 

PROVIDER: S-EPMC11779709 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature