Exploring the composition of placental microbiome and its potential origin in preterm birth.

ABSTRACT:

Introduction

For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about the origins of the placental microbiome and its effects on pregnancy and fetal health. Some studies suggest it may originate from the vaginal tract, while others indicate that oral bacteria can enter the maternal bloodstream and seed the placenta. However, research analyzing the vaginal, oral, and placental microbiomes within the same cohort is lacking. Additionally, it's unclear whether the placental microbiome differs between healthy pregnancies and those with complications like preterm birth (PTB), which remains a leading cause of neonatal morbidity and mortality worldwide.

Methods

In this study

SUBMITTER: Saadaoui M 

PROVIDER: S-EPMC11779731 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature