Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas.

ABSTRACT: The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A pro

SUBMITTER: May M 

PROVIDER: S-EPMC11779799 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature