ScATAC-seq generates more accurate and complete regulatory maps than bulk ATAC-seq.

ABSTRACT: Bulk ATAC-seq assays have been used to map and profile the chromatin accessibility of regulatory elements such as enhancers, promoters, and insulators. This has provided great insight into the regulation of gene expression in many cell types in a variety of organisms. To date, ATAC-seq has most often been used to provide an average evaluation of chromatin accessibility in populations of cells. The development of a single cell approach (scATAC-seq) assay enables researchers to evaluate chromatin accessibility in individual cells and identify sub-groups in mixed populations of cells. To investigate the full potential of single-cell epigenomic data, we have comprehensively compared the information derived from bulk ATAC-seq and scATAC-seq in populations of cells. We found that the chromatin a

SUBMITTER: Gur ER 

PROVIDER: S-EPMC11779887 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature