Novel Pt (II) Complexes With Anticancer Activity Against Pancreatic Ductal Adenocarcinoma Cells.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of solid tumor that is becoming more common. cis-[PtCl₂ (NH₃)₂] (in short cisplatin or CDDP) has been shown to be effective in treating various cancers, including PDAC. However, the development of resistance to chemotherapy drugs has created a need for the synthesis of new anticancer agents. Platinum-based drugs containing the bidentate ligand phenanthroline have been found to have strong antitumor activity due to their ability to cause DNA damage. In this study, we examined the ability of two Pt (II) cationic complexes, [Pt(η ¹-C₂H₄OR) (DMSO) (phen)]⁺ (in short Pt-EtORSOphen; R = Me, 1; Et, 2), to inhibit the gr

SUBMITTER: Stefano E 

PROVIDER: S-EPMC11779987 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature