A Prognostic Riskscore Model Related to Helicobacter pylori Infection in Stomach Adenocarcinoma.

ABSTRACT: Background: Helicobacter pylori (HP) is associated with the development of various stomach diseases, one of the major risk factors for stomach adenocarcinoma (STAD). Methods: The HP infection score between tumor and normal groups was compared by single-sample gene set enrichment analysis (ssGSEA). The key modules related to HP infection were identified by weighted gene coexpression network analysis (WGCNA), and functional enrichment analysis was conducted on these module genes. Further, the limma package was used to screen the differentially expressed genes (DEGs) between HP-positive and HP-negative STAD. The prognostic genes were obtained to construct the riskscore model, and the performance of the model was validated. The correlatio

SUBMITTER: Peng J 

PROVIDER: S-EPMC11779996 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature