Goal-Directed Versus Self-Directed Valsalva Maneuver in Patients With Hypertrophic Cardiomyopathy on Cardiac Myosin Inhibitor Therapy.

ABSTRACT:

Background

The Valsalva maneuver is essential in evaluating left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic cardiomyopathy (HCM). Traditionally, a self-directed Valsalva (SDV) maneuver is taught to patients using vague instructions such as "bear down." SDV is often not performed correctly leading to variable results and underestimation of the true provocable LVOT gradient. Alternatively, a standardized, goal-directed Valsalva (GDV) approach by maintaining an intraoral pressure 40 mm Hg for 10 seconds or more provides a more objective, reproducible result. Accurate and reproducible LVOT gradient is key in the mavacamten algorithm for dose titration.

Objectives

The objective was to evaluate the clinical impact of the GDV compared to SDV in patie

SUBMITTER: Bavishi A 

PROVIDER: S-EPMC11780103 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature