Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology.

ABSTRACT:

Introduction

Clinicopathological correlations differ by sex in Lewy body dementia (LBD). However, previous studies have focused on pathological staging systems that place less emphasis on regional pathologies.

Methods

We included 357 people (131 female, 226 male) with a high likelihood of LBD based on pathology from the Brain Bank for Neurodegenerative (Jacksonville, FL). Sex differences for regional Lewy body, senile plaque, and neurofibrillary tangle counts and their associations with clinical LBD diagnosis were assessed.

Results

Females were less likely to have a clinical LBD diagnosis; they had more Lewy bodies, neurofibrillary tangles, and senile plaques in various regions than males (all p's < 0.05). A higher likelihood of clinical LBD diagnosis was assoc

SUBMITTER: Bayram E 

PROVIDER: S-EPMC11780110 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature