Age-disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra.

ABSTRACT:

Introduction

Brain age gap (BAG), defined as the difference between MRI-predicted 'brain age' and chronological age, can capture information underlying various neurological disorders. We investigated the pathophysiological significance of the BAG across neurodegenerative disorders.

Methods

We developed a brain age estimator using structural MRIs of healthy-aged individuals from one cohort study. Subsequently, we applied this estimator to people with Alzheimer's disease spectra (AD) and Parkinson's disease (PD) from another cohort study. We investigated brain sources responsible for BAGs among these groups.

Results

Both AD and PD exhibited a positive BAG. Brain sources showed overlapping, yet partially segregated, neuromorphological differences between these groups. Fu

SUBMITTER: Yoshinaga K 

PROVIDER: S-EPMC11780112 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature