Impact of sleep disruptions on gray matter structural covariance networks across the Alzheimer's disease continuum.

ABSTRACT:

Background

This study explores the impact of sleep disturbances on gray matter structural covariance networks (SCNs) across the Alzheimer's disease (AD) continuum.

Methods

Amyloid-negative participants served as controls, whereas amyloid positive (A+) individuals were categorized into six groups based on cognitive status and sleep quality. SCNs for the default mode network (DMN), salience network (SN), and executive control network (ECN) were derived from T1-weighted magnetic resonance images.

Results

In the DMN, increased structural associations were observed in cognitive unimpaired (CU) A+ and mild cognitive impairment (MCI) groups regardless of sleep quality, whereas AD with poor sleep (PS) showed a decrease and AD with normal sleep (NS) an increase. For the ECN, A

SUBMITTER: Luo X 

PROVIDER: S-EPMC11780114 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature