Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.

ABSTRACT:

Introduction

We examined the associations of carotid intima-media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases (CVD) and dementia in the UK Biobank cohort.

Methods

The study consisted of 42,711 participants (mean age 64.2 years) with brain magnetic resonance imaging (MRI), vascular assessments, and cognitive testing. Cerebrovascular disease markers included white matter hyperintensities (WMH) and brain volumes. CIMT, ASI, and PP were measured using carotid ultrasound, photoplethysmography, and blood pressure, respectively. General cognitive ability (g-score) was derived from various cognitive tests using principal components analysis (PCA).

SUBMITTER: Robert C 

PROVIDER: S-EPMC11780115 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature