Clinical and neuropathological associations of plasma Aβ₄₂/Aβ₄₀, p-tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders.

ABSTRACT:

Introduction

Plasma amyloid beta₄₂/amyloid beta₄₀ (Aβ₄₂/Aβ₄₀) and phosphorylated tau217 (p-tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co-pathology in the setting of other primary neurodegenerative diseases, but this has not been systematically studied.

Methods

We compared the clinical, neuroimaging, and neuropathological associations of plasma Aβ₄₂/Aβ₄₀ (mass spectrometry), p-tau217 (electrochemiluminescence), and neurofilament light ([NfL], single molecule array [Simoa]), as markers of AD co-pathology, in a sporadic frontotemporal dementia (FTD) cohort (n = 620).

Results

Aβ₄₂/Aβ₄₀ showed no clinicopathological associations. High p

SUBMITTER: Rajbanshi B 

PROVIDER: S-EPMC11780117 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature