Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy.

ABSTRACT:

Objective

Although DNA methylation has been suggested to be a potential predictor of the progression of obesity and obesity-related diseases, little is known about its potential role as predictive marker of successful weight loss after bariatric surgery.

Methods

20 patients who underwent sleeve gastrectomy were classified according to the percentage of excess weight loss (%EWL) 1 year after bariatric surgery, using 60% as the cut-off point. Blood DNA methylation was analyzed prior to surgery using the Infinium Methylation EPIC Bead Chip array-based platform.

Results

A total number of 76,559 differentially methylated positions (DMPs) (p < 0.05) were found between <60% EWL and >60% EWL groups. Of them, 59,308 DMPs were annotated to genes. KEGG enrichment analysis showed

SUBMITTER: Paz-Lopez G 

PROVIDER: S-EPMC11780120 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature