Effective function annotation through catalytic residue conservation.

ABSTRACT: Because of the extreme impact of genome sequencing projects, protein sequences without accompanying experimental data now dominate public databases. Homology searches, by providing an opportunity to transfer functional information between related proteins, have become the de facto way to address this. Although a single, well annotated, close relationship will often facilitate sufficient annotation, this situation is not always the case, particularly if mutations are present in important functional residues. When only distant relationships are available, the transfer of function information is more tenuous, and the likelihood of encountering several well annotated proteins with different functions is increased. The consequence for a researcher is a range of candidate functions with little w

SUBMITTER: George RA 

PROVIDER: S-EPMC1178014 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature