Inter-Laboratory Validation of Nodal/Paranodal Antibody Testing.

ABSTRACT:

Background and aims

Reliable detection of antibodies against nodal targets is vital for the diagnosis of autoimmune nodopathies. The performance characteristics of recently developed in-house assays are unknown. We compared testing at four centres.

Methods

Each submitted 29-40 serum samples to a coordinating centre from one of three groups: (1) autoimmune nodopathy patients, with positive nodal/paranodal antibodies; (2) seronegative patients with other inflammatory neuropathies, and (3) healthy individuals or those with other neurological diseases. The coordinating centre recoded all samples and returned 160 identical aliquots to each testing centre for blinded testing. Once data from all centres had been received by the coordinating centre, unblinded results were returned f

SUBMITTER: Lleixa C 

PROVIDER: S-EPMC11780190 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature