Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis.

ABSTRACT:

Introduction

We aimed to identify unique proteomic signatures of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD).

Methods

We conducted a comparative proteomic analysis of 33 post mortem brains from AD, DLB, and PDD individuals without dementia focusing on prefrontal, cingulate, and parietal cortices, using weighted gene co-expression network analyses with differential enrichment analysis.

Results

Network modules revealed hub proteins common to all dementias. Lewy body dementias differed from AD by reduced levels of the autophagy protein p62 (SQSTM1), whereas DLB was distinguished from both AD and PDD by altered TRIM33 and cysteine/glutamate transporter (SLC7A11) across brain regions. An increase in mitochondrial and sy

SUBMITTER: Canal-Garcia A 

PROVIDER: S-EPMC11780320 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature