PH-Sensitive oligopeptide magnetic mesoporous silica beads for deoxyribonucleic acid extraction.

ABSTRACT: Exploring novel synthesis strategies for magnetic beads to extract nucleic acids is of great significance in the field of in vitro diagnostics. In the present research, monodisperse magnetic mesoporous silica beads were synthesized via the thermolysis reaction of Fe(acac)₃ by using large-pore dendritic silica colloids as templates, and were further functionalized with a highly pH-sensitive histidine-glutamate co-oligopeptide for deoxyribonucleic acid extraction. The large-pore dendritic silica colloid scaffolds were utilized for high-density incorporation of superparamagnetic iron oxide nanoparticles within the vertical channels. The morphology and properties of the as-prepared pH-sensitive oligopeptide magnetic mesoporous silica beads were evaluated by transmissio

SUBMITTER: Qian S 

PROVIDER: S-EPMC11780327 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature