Jellyfish Collagen Grafted with Hydroxybutyl Chitosan and Protocatechuic Acid Adhesive Sponge with Antibacterial Activity for Rapid Hemostasis.

ABSTRACT: Natural jellyfish collagen (JC) has garnered significant attention in the field of hemostasis due to its oceanic origin, nontoxicity, biodegradability, and absence of complications related to diseases and religious beliefs. However, the hemostatic performance of pure JC is limited by its poor stability, adhesion to wet tissue, and mechanical properties. We developed a novel (HJP) sponge comprising JC, protocatechuic acid (PA), and hydroxybutyl chitosan (HS) to enhance the application of JC in emergency hemostasis. This sponge exhibits antibacterial properties, good biocompatibility, wet tissue adhesion, and hemostatic capabilities. The HJP sponge demonstrates excellent thermal stability and mechanical strength (tensile strength: ∼106.6 kPa, compressive strength at 70% compressive strain: ∼

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11780408 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature