Novel Tapentadol Screen-Printed Carbon Sensor Integrated Copper Oxide Nanostructure.

ABSTRACT: The present study described the fabrication and electroanalytical performance of planar screen-printed disposable sensors based on copper oxide nanoparticles (CuONPs/SPEs) for the voltammetric determination of tapentadol (TAP) in its marketed pharmaceutical products and biological fluids. CuONPs exhibited electrochemical activity against the electrooxidation of TAP with an anodic peak at 0.84 V in the BR buffer at pH 5. The electroanalytical investigations and molecular orbital calculations pointed out the oxidation of the tertiary amine group within the TAP moiety with the transfer of two electrons and protons during the oxidation of the TAP molecule at the CuONPs/SPEs surface. Linear calibration graphs were constructed covering the TAP concentration ranging from 0.83 to 738 ng mL^-1<

SUBMITTER: Snari RM 

PROVIDER: S-EPMC11780419 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature