A free-radical initiator-based carrier-free smart nanobomb for targeted synergistic therapy of hypoxic breast cancer.

ABSTRACT: Thermodynamic therapy (TDT) is a promising alternative to photodynamic therapy (PDT) by absorbing heat through thermosensitive agents (TSAs) to generate oxygen-irrelevant highly toxic free radicals. Therefore, TDT can be a perfect partner for photothermal therapy (PTT) to achieve efficient synergistic treatment of anoxic tumors using a single laser, greatly simplifying the treatment process and overcoming hypoxia limitations. However, the issues of how to improve the stability and delivery efficiency of TSAs still need to be addressed urgently. Herein, polyethylene glycol-folic acid (PEG-FA)-modified and indocyanine green (ICG)-encapsulated nanoscale Zn²⁺ and 2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) coordinated nanomaterials (IANM-PEG-FA) were developed as

SUBMITTER: Hu L 

PROVIDER: S-EPMC11780488 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature