Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and Lesotho: A Randomized Clinical Trial.

ABSTRACT:

Importance

Hypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple combination remain unclear.

Objectives

To compare the effect of 3 treatment strategies on blood pressure control among persons with untreated hypertension in Africa.

Design, setting, and participants

This was an open-label, parallel, 3-arm randomized clinical trial to evaluate noninferiority of a strategy starting 2 pills vs full-dose monotherapy with stepped escalation (noninferiority margin 10%) and superiority of starting low-dose 3 pills vs monotherapy allowing for monthly up titration. Recruitment lasted from March 5, 2020, to March

SUBMITTER: Mapesi H 

PROVIDER: S-EPMC11780507 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature