Improved Outcomes and Resource Use With Normothermic Machine Perfusion in Liver Transplantation.

ABSTRACT:

Importance

Normothermic machine perfusion (NMP) has been shown to reduce peritransplant complications. Despite increasing NMP use in liver transplant (LT), there is a scarcity of real-world clinical experience data.

Objective

To compare LT outcomes between donation after brain death (DBD) and donation after circulatory death (DCD) allografts preserved with NMP or static cold storage (SCS).

Design, setting, and participants

This single-center, retrospective observational cohort study included all consecutive adult LTs performed between January 2019 and December 2023 at the Mayo Clinic in Arizona. Data analysis was performed between February 2024 and June 2024. Outcomes of DBD-SCS, DBD-NMP, DCD-SCS, and DCD-NMP transplants were compared.

Exposure

DBD and DCD live

SUBMITTER: Nguyen MC 

PROVIDER: S-EPMC11780509 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature