Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy.

ABSTRACT: Rationale: Lung cancer remains a major global health burden with limited therapeutic options. Alternative splicing, a critical post-transcriptional process, contributes to lung cancer progression through autophagy, although the underlying mechanisms remain largely unexplored. This study aims to elucidate the role of DDX24 as a splicing factor that contributes to lung cancer progression via autophagy. Methods: To establish the link between DDX24 and lung cancer progression, we performed colony formation assays, growth curve analyses, and xenograft tumor models in nude mice. Mass spectrometry and RNA sequencing were employed to investigate the involvement of DDX24 in alternative splicing, with a specific focus on the splicing of IKBKG. The mechanisms by which DDX24 regulates au

SUBMITTER: Sun S 

PROVIDER: S-EPMC11780526 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature