Shear stress unveils patient-specific transcriptional signatures in PAH: Towards personalized molecular diagnostics.

ABSTRACT: Rationale: Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by increased pulmonary blood pressures and regional inhomogeneities in flows, with diagnostic and treatment challenges arising from diverse underlying pathogenic mechanisms. Conventional in vitro models often obscure the mechanistic nuances of PAH by failing to replicate the dynamic mechanical environment of the diseased lung, limiting the identification of specific molecular patterns. To address this, we employed an in vitro shear stress model simulating physiological or pathological conditions to explore the transcriptional heterogeneity of human pulmonary microvascular endothelial cells (hPMECs) from PAH patients and healthy controls within their respective biomechanical co

SUBMITTER: Wittig C 

PROVIDER: S-EPMC11780538 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature