Bioethics of somatic gene therapy: what do we know so far?

ABSTRACT:

Objective

To provide a systematic overview of bioethical debate on somatic gene therapy as documented in the scientific literature.

Methods

We performed a systematic review of reasons, following Strech and Sofaer approach, which is a method to systematically identify and classify arguments (reasons) used in the scientific literature. We identified 217 eligible publications retrieved from PubMed, Lilacs, PhilPapers, and Google Scholar. A meta-synthesis was performed to analyze the data.

Results

We extracted 189 arguments. Arguments were grouped into 23 categories. Twelve categories were classified as research-related, including the risk/benefit ratio, priorities and limits, informed consent, review, and monitoring. Eleven were classified as society-related, including p

SUBMITTER: Buedo P 

PROVIDER: S-EPMC11780552 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature