Scalable and Practical Approach of Phenol Formation from Hydroxylation of Arylboronic Acids under Metal-, Photocatalyst-, and Light-Free Conditions.

ABSTRACT: Phenols are of particular importance owing to their widespread application in various fields, including life sciences and synthetic chemistry. However, the typical synthetic strategies of phenol either rely on metal- or photo-catalysts or involve stringent conditions such as high temperature, strong oxidants, and acidic or basic environments. Herein, we present a remarkably simple, ecofriendly, and photocatalyst-free synthesis of phenols. In contrast to conventional methods, which relies on expensive catalysts or hazardous reagents, the current diacetoxyiodobenzene-mediated hydroxylation of arylboronic acid protocol offers significant improvement in terms of costs, operational simplicity, toxicity, and sustainability. The reaction does not require high temperature or light activation and s

SUBMITTER: Cai S 

PROVIDER: S-EPMC11780564 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature