The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [¹⁴C]Binimetinib 45 mg in Healthy Male Participants.

ABSTRACT: Binimetinib is a MEK1/2 inhibitor particularly active in cells harboring activating mutations in the MAP kinase pathway, especially in BRAF and NRAS. Binimetinib, in combination with encorafenib, has received marketing approval in several jurisdictions for the treatment of patients with BRAF V600E or V600K mutant melanoma. The absorption, distribution, metabolism, and excretion of binimetinib were evaluated by administering a carbon 14-labeled binimetinib 45 mg dose (containing 40 μCi of radiolabeled material) to 6 healthy male participants. A total of 62.3% of the radioactivity was eliminated in the feces, while 31.4% was eliminated in the urine. The overall recovery of radioactivity in the excreta for all 6 participants was 93.6% (3.27%), indicating that good mass balance was achieved. T

SUBMITTER: Huynh D 

PROVIDER: S-EPMC11780716 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature