Read-Across of Biotransformation Potential between Activated Sludge and the Terrestrial Environment: Toward Making It Practical and Plausible.

ABSTRACT: Recent emphasis on the development of safe-and-sustainable-by-design chemicals highlights the need for methods facilitating the early assessment of persistence. Activated sludge experiments have been proposed as a time- and resource-efficient way to predict half-lives in simulation studies. Here, this persistence "read-across" approach was developed to be more broadly and robustly applicable. We evaluated 21 previously used reference plant protection products (PPPs) for their broader applicability in calibrating regression and classification models for predicting half-lives in soil (DT50_OECD307) and water-sediment systems (DT50_OECD308) based on their half-life in sludge and the organic carbon-water partition coefficient K_OC as predictors. The calibra

SUBMITTER: Coll C 

PROVIDER: S-EPMC11780744 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature