Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study.

ABSTRACT:

Background

The DNA methylation-based epigenetic clocks are increasingly recognized for their precision in predicting aging and its health implications. Although prior research has identified connections between accelerated epigenetic aging and multiple sclerosis, the chronological and causative aspects of these relationships are yet to be elucidated. Our research seeks to clarify these potential causal links through a bidirectional Mendelian randomization study.

Methods

This analysis employed statistics approaches from genome-wide association studies related to various epigenetic clocks (GrimAge, HannumAge, PhenoAge, and HorvathAge) and multiple sclerosis, utilizing robust instrumental variables from the Edinburgh DataShare (n = 34,710) and the International Multiple Scleros

SUBMITTER: Liu H 

PROVIDER: S-EPMC11780769 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature