C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation.

ABSTRACT:

Background

Preeclampsia, characterized by hypertension and proteinuria during pregnancy, poses significant risks to both mother and fetus. The complement system's aberrant activation, notably the C3AR1, is important to the pathogenesis of preeclampsia, although the precise mechanisms are not fully understood.

Materials and methods

Utilizing the Comparative Toxicogenomics Database (CTD) and Molecular Signatures Database (MSigDB), we identified complement system targets associated with preeclampsia and environmental pollutants. Expression validation was conducted through the Gene Expression Omnibus (GEO) database. Molecular docking predicted interactions between BPA, PFOS, and C3AR1. Immunohistochemical staining of 80 placental tissues (40 early-onset preeclampsia and 40 healt

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11780793 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature