Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer.

ABSTRACT:

Background

The homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi). Using whole exome sequencing (WES)-based platform can provide information of gene mutations and HRD score; however, the clinical value of WES-based HRD test was less validated in EOC.

Methods

We enrolled 40 patients with EOC in the training cohort and 23 in the validation cohort. The WES-based HRD score was calculated using the scarHRD software. We first evaluated the concordance of the HRD status defined by the Myriad MyChoice CDx and then assessed the value of HRD on clinical prognosis in patients with EOC.

Results

The HRD score

SUBMITTER: Chiang YC 

PROVIDER: S-EPMC11780812 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature