Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models.

ABSTRACT: The generation of retinal models from human induced pluripotent stem cells holds significant potential for advancing our understanding of retinal development, neurodegeneration, and the in vitro modeling of neurodegenerative disorders. The retina, as an accessible part of the central nervous system, offers a unique window into these processes, making it invaluable for both study and early diagnosis. This study investigates the impact of the Frontotemporal Dementia-linked IVS 10 + 16 MAPT mutation on retinal development and function using 2D and 3D retinal models derived from human induced pluripotent stem cells. Our findings reveal that the MAPT mutation leads to delayed retinal cell differentiation and maturation, with tau-mutant disease models exhibiting sustained higher expression of re

SUBMITTER: Mautone L 

PROVIDER: S-EPMC11780910 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature