Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis.

ABSTRACT: UBE2M, an essential neddylation E2 enzyme, has been implicated in the pathogenesis of various diseases, including cancers, viral infections, and obesity. However, whether UBE2M is involved in the pathogenesis of bacterial sepsis remains unclear. In an Escherichia coli (E. coli)-induced sepsis mouse model, increased UBE2M expression in macrophages in liver and lung tissues postinfection was observed. To further clarify the role of UBE2M in macrophages, mice with macrophage-specific deletion of UBE2M (Lysm⁺Ube2m^f/f) were constructed. Compared with control mice, these mice presented decreased levels of proinflammatory cytokines, such as IL-1β, IL-6, and TNF-α; reduced sepsis-induced organ injury; and improved survival. Notably, macrophage-specific deletion of UBE2M did n

SUBMITTER: Wen X 

PROVIDER: S-EPMC11780929 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature