Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression.

ABSTRACT: Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play a crucial role in brain development and function, potentially serving as a crossroad for the abnormalities in neurotransmitters, neuroendocrine, inflammation, oxidative stress, and energy metabolism observed in depressed adolescents. The primary aim of this study was to investigate the erythrocyte membrane lipid profile in adolescent depression. A total of 2838 erythrocyte membrane lipids were detected and quantified in 81 adolescents with depression and 67 matched healthy adolescents using ultra-high performance liquid chromatography-mass spectrometry. Depressed adolescents exhibited significantly different membrane lipid characteristics compar

SUBMITTER: Wang J 

PROVIDER: S-EPMC11780951 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature