Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one common tumor with the high death rate, and badly affects the normal lives of CRC patients. Amarogentin (AG) has been found to exhibit regulatory roles and join into the progression of multiple diseases. However, the regulatory impacts and associated molecular mechanisms of AG in CRC progression keep unclear.

Methods and results

In this study, it was demonstrated that AG weakened CRC cell viability in a concentration- and time-dependent manner. In addition, AG accelerated cell apoptosis by triggering ferroptosis. The cell invasion and EMT process were restrained after AG treatment, but these impacts were reversed after Fer-1 addition. Moreover, it was uncovered that AG retarded Nrf2/HO-1/GPX4 activation. Additionally, AG modulated PTC

SUBMITTER: Wang C 

PROVIDER: S-EPMC11780999 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature